Desenvolvimento e padronização de produto seco por aspersão de Vismia guianensis (Aubl.) Choisy com atividade antifúngica

Abstract

In the Amazon, the use of medicinal plants by native and riverine population is an important source of ethnopharmacological knowledge. One of the plants widely used with medicinal properties, is Vismia guianensis (Aubl) Choisy. The sap (reddish resin) obtained from the infusion of bark and leaves are widely used in folk medicine against white cloth (PV) and impinges (Tinea corporea). The development of the fungi that cause skin conditions, among other factors, is favored by the tropical climate of northern Brazil. Thus, this plant species is very promising for technology studying the sensing processing of the plant material in a standardized product which can be used with safety and therapeutic efficacy. In this sense, the present study aimed to the development and standardization of a spray dried extract of V. guianensis with proven antifungical activity. For this were used leaves as raw material, such that was characterized by pharmacopoeial techniques and not pharmacopoeial. Using a factorial design was obtained, optimized and standardized a solution with antifungal activity, from which the ESA was obtained (spray dried extract) and PSA (spray dried product), they have also been characterized and these were characterized and evaluated for antifungal activity by microdilution method. Both dry extracts showed antifungal activity against fronts of Candida albicans, Malassezia furfur and Trichophyton rubrum with MIC (minimum inhibitory concentration) ranged from 0,5 to 8 mg / mL, however, the PSA showed better performance characteristics and physical stability. With all this, it appears that the spray dried extracts of Vismia guianensis have technological characteristics that enable its future transformation into a pharmaceutical form.