Avaliação morfológica e funcional de plaquetas associada à comorbidades respiratórias em pacientes HIV/AIDS

Abstract

Respiratory comorbidities is major causes of hospital admission among people living with HIV worldwide, and their outcome is poor when associated with opportunistic coinfections. This study aimed to evaluate the morphological and functional aspects of the platelets of HIV/AIDS patients with respiratory comorbidities. In this study, tuberculosis coinfected HIV/AIDS (HIV/AIDS-TB) patients showed a higher risk of death, higher IL-6 levels was associated with death (p=0.028), comorbidities (neurological and digestive), hematological manifestations (p=0.0094) and CD4+T cell counts (p=0.0105). Platelet abnormalities observed in HIV/AIDS-TB were due either thrombocytopenia (p=0.0059) or thrombocytosis (p=0.022). Morphological analysis showed different behavior of two subpopulations of CD41+/DHE+ (reticulated) and CD41+/DHE- (mature) platelets when they were stimulated with adrenaline. The mature platelets of HIV/AIDS-TB responded increasing the number of events suggesting fragmentation of this subpopulation. Although the mechanism involved in these complications is unclear, inflammation and changes in platelet responses appear to be important factors associated with progression of HIV infection and death.