Desenvolvimento de filme à base de amido amazônico e blendas poliméricas para liberação transdérmica de naringenina

Abstract

The administration of drugs through the transdermal route has been explored as an alternative to the infeasibility of administering pharmacologically active substances that have low bioavailability through the oral route. Among the pharmaceutical forms used, films can enable the controlled delivery of drugs through the skin, from polymeric membranes, capable of improving the therapeutic efficacy of these drugs. Naringenin is a product of natural origin, classified as a flavonoid and has several therapeutic activities due to its anti-inflammatory and antioxidant properties. Due to its low oral bioavailability, the use of transdermal delivery systems appears as an option. The aim of this work was to develop a starch-based biodegradable transdermal delivery film containing naringenin and evaluate it for skin permeation. Different sources of starch were used, namely, starch from corn, sweet potato and aria potato (Goeppertia allouia). The films were characterized in terms of thickness, mechanical properties, colorimetry, hydration capacity, moisture content and homogeneity. In vitro release, permeation and skin retention assays were also performed. Stability was analyzed over 60 days. All films presented excellent values regarding mechanical characteristics, however the control film with PVA/PVP blend for aria potato starch surprised with a 400% increase in deformation in relation to its initial size when subjected to tension. Cutaneous permeation for the cornstarch-based film showed greater drug control, with kinetics close to zero order, crucial for obtaining a systemic action. For the same test, the film based on ariá potato maintained its concentration for 24 h, proving to be a viable proposal for using the benefits of naringenin in skin treatments with local action. This study also provides additional information on the regional Amazonian tuber Goeppertia allouia, being the first work to study its application in the pharmaceutical industry.