Avaliação da atividade antimicrobiana e citotóxica de novos compostos triazólicos

Abstract

The search for new antimicrobial agents is necessary due to the emergence of resistant microorganisms and fatal opportunistic infections associated with the acquired immunodeficiency syndrome (AIDS), cancer chemotherapy and transplantation. The triazole compounds are one of the most studied heterocyclic systems today and have attracted much interest because they have a wide range of applications, ranging from use as explosives, even as agrochemicals and pharmaceuticals. This study aimed to evaluate the antimicrobial activity of synthetic 1,2,3 triazole compounds in yeasts Candida sp, the bacteria Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis and filamentous fungi Microsporum canis, Trichophyton rubrum and Aspergillus niger using the technique of microdilution and evaluate the cytotoxicity of the compounds showed antimicrobial activity tests for cell viability in fibroblasts NIH3T, hemolytic potential in human blood and anticoagulant activity in human plasma. Of all the compounds screened, four showed good anti-candida (MIC 0.25 to 0.06 mmol/L). These same compounds also show activity for M. canis (MIC 50-100 mg/mL), T. rubrum (25 MIC 6.25 mg/mL) and A. niger (MIC 100 mg/mL). None of the compounds tested showed antibacterial activity for P. aeruginosa, S. aureus and E. faecalis. All compounds showed antifungal activity showed low cytotoxicity for the tests analyzed. From screening of 90 new compounds were identified four 1,2,3 triazole which may have potential for the development of new drugs with antifungal activity