Infecção pelo vírus Zika em uma população da Amazônia Ocidental Brasileira: estudo da resposta imune, características clínicas e de diagnóstico

Abstract

Zika virus (ZIKV) is an emergent arbovirus of the family Flaviviridae and the genus Flavivirus, which until 2007 was restricted to some cases of mild disease in Africa and Asia. In Brazil, it`s suspected that the entry of the virus occurred during the 2013 Confederations Cup and in the first half of 2015, there were already confirmed cases in states in all regions of the country. The Brazilian epidemic revealed that the usually mild and self-limiting infection could be related to neurological disorders. The objectives of this study were to clarify numerous questions regarding ZIKV infection, aiming to contribute to a better understanding of the mechanisms involved in the immunopathogenesis and course of the disease. As a result, the first report of atrial fibrillation in patients with Zika was described and could be considered an atypical manifestation during the virus infection; elevation of proinflammatory cytokines during ZIKV infection was observed; CXCL10 chemokine was identified as a potential biomarker for infection; saliva was characterized as the fluid of choice for the detection of Zika virus in the acute phase of the disease and a logistic regression model for the classification of cases of zika in relation to dengue was set up based on the clinical evaluation.