Determinação de lansoprazol em cápsulas utilizando metodologia baseada em imagens digitais

Abstract

In this paper, we propose the determination of lansoprazole content, selective inhibitor of H + / K + -ATPase gastric using titration based on digital image (Digital Image-Based Titration). The DIB system uses a webcam to acquisition of digital images based on the color system RGB (Red-Green-Blue). During the titration procedure the method was applied to the acid-base titration of the drug lansoprazole with hydrochloric acid. The titration was performed by the DIB, and by potentiometry. In DIB methodology for each volume of titrant added an image was captured and manipulated to obtaining the standard values (N=√R̅2+G̅2+B̅2). The spent volume of titrant to reach the equivalence point was obtained from the second derivative of the titration curve. The results of the samples showed no statistically significant differences at the 95% confidence level was observed after applying the paired t test (tcalculado = 0,439 e tcrítico = 2,353). The relative standard deviations using the DIB methodology with the exception of Sample C, was below 1.0%.