Avaliação da aplicabilidade de membranas de Poli (e-caprolactona) carregadas com fármacos no tratamento de feridas

Abstract

The ideal coverage of wounds has been a challenge for humanity since the beginning. The desire for a quick, effective and painless treatment, led to the search for skin substitutes for the lesions that generated the loss of protection given by its natural barrier to aggressive agents, with delayed healing and prolonged suffering, causing increased tissue damage. and pain. Man has already sought the ideal ointment on land, at sea and even in the air, researching the benefit of some gases. Technological advancement with the appearance of the nanoscale has brought us back to electrospinning, allowing us to re-evaluate the application, a centuries-old process of making materials, with widespread use in industry, combined with new substances for research in the health area. OBJECTIVE: General: Evaluation of the applicability of poly (ε - caprolactone) membranes loaded with drugs in the treatment of wounds. Specifics: Check which types of wounds HS and AGE loaded membranes and pure PCL membranes are applicable to. Compare effectiveness between drug loaded membranes and pure PCL membranes. Estimate the cost-benefit ratio in the application of the membranes. METHOD: observational, prospective, randomized, and controlled study with the participation of patients with clean or potentially contaminated wounds in patients admitted to the Hospital e Pronto Socorro 28 de Agosto, in the city of Manaus - Reference hospital in Amazonas. Patients were randomly assigned to three groups: Group 1 - 8 patients treated with pure membrane. Group 2 - 8 patients treated with membrane releasing sodium heparin, Group 3 - 8 patients treated with membrane Essential Fatty Acids. The results were obtained by comparing the groups, with treatment by Friedman's nonparametric method. RESULTS: There were statistically significant differences in the characteristics of malleability, adhesion, transparency, with superiority of the pure membrane in relation to the others. The low absorption capacity of all membranes leads to the indication for covering non-secreting lesions. All membranes allowed an important decrease in the pain of the treated patients and there was no infection, confirming the effectiveness of the ozone sterilization method. CONCLUSIONS: all membranes used in this research have good applicability with an indication for lesions that affect up to the deep dermis, and there is a need to make macropores to evaluate the possibility of application in higher grade lesions. The low cost of production was found and, finally, the great savings generated with the application of this material were observed, highlighting the significant importance of continuing this research for the benefit of the population.