Metabólitos fúngicos com potencial antimicrobiano isolados e caracterizados produzidos por gênero Fusarium: uma revisão sistemática da literatura

Abstract

The recurrent characterization of the same bioactive compounds by filamentous fungi can cause disinterest in the biotechnological issue as well as on the part of industry. The problem raised by researchers is mainly in the form of the standard cultivation process. Many of these fungal microorganisms, when placed in standard culture media in laboratories, are unable to express other genes that synthesize new secondary metabolites. Therefore, it is necessary to identify which bioactive fungal metabolites have been characterized so that new compounds can be isolated. Therefore, the objective of this work was to survey through the steps of systematic literature review of fungal metabolites isolated and characterized by Fusarium genus. Scielo, Scopus, Lilacs, WebofScience and Medline were used to identify articles published between the years and 1991 to 2020. The key words "Fusarium", "metabolite" and "antimicrobial" were used to separate each one article that fit the question set in this paper, "Which fungal metabolites isolated and characterized from Fusarium genus that have antimicrobial potential?". After an initial search, 7967 scientific articles were found from all databases. Despite this number, only 438 articles presented bioactive metabolites extracted from the genus. Next, the systematic review steps were performed. 64 articles were identified to identify the data. In all, 57 metabolites with antifungal and antibacterial potential were found. Among these, compounds from the quinone and non-ribosomal peptide classes were the most found. Finally, the present work brings a record of bioactive compounds synthesized during the last 30 years to optimize the search for new metabolites produced by the genus Fusarium.