Desenvolvimento e caracterização de hidrogel de carboximetilcelulose ativo com óleo essencial de pau rosa com potencial curativo dérmico.

Abstract

Hydrogels are central points of current research due to their potential applications in several fields, which include tissue engineerings, such as dressings, sensors, packaging films, and the transport of bioactive, among others. Recently, materials for dressings based on sodium carboxymethylcellulose (CMC-Na) have been attractive due to their remarkable biocompatibility properties, biodegradability, tissue similarity, low cost, and non-toxicity. The essential oil extracted from the rosewood tree has anti-inflammatory, analgesic, bactericidal, and fungicidal properties, with great potential to be applied as an active ingredient in a CMC hydrogel polymeric matrix. Rosewood oil (Aniba rosaeodora Ducke) has linalool as its major constituent, a tertiary alcoholic monoterpene. The encapsulation system of active principles provides control over the release of the active, enhancing and prolonging its action in the environment. Essential oils encapsulated and incorporated into a matrix of reticulated hydrogels make up a system that inhibits the growth of bacteria and fungi. Given this context, this study developed and characterized hydrogel films based on CMC-Na interspersed with citric acid and actives with rosewood essential oil (EO) nano encapsulated in aqueous emulsion, aiming at future applications as dermal dressings. The methodology adopted to obtain the nanocapsules was satisfactory, with an average size of 122 nm, analyzed by DLS. The H3% and H3%OE hydrogel film showed a degree of swelling between 3500 and 3800%, and the H5% and H5%OE between 1000 and 1500%, with diffusion coefficients (D) between 0.15.1010 m2/s and 1.6.1010 m2/s. The volume of oil released by the emulsion in 24 h was 12.54 mL/L. The FTIR analysis allowed the chemical characterization, elucidating the presence of the main chemical groups and their interactions. The TGA/DSC analyses showed that the thermal stability properties of the cellulose films were maintained, even after the addition of EO. The SEM showed the films' morphological characteristics, regarding the surface's uniformity and homogeneity, without the presence of voids (voids). All these parameters indicate that the developed hydrogel films have excellent potential for future applications as dermal dressings.