Co-infecção do papilomavírus humano e chlamydia trachomatis em mulheres com citologia normal e alterada

Abstract

The cervical cancer is the second most common type of cancer between women worldwide. In Brazil, 18.430 new cases of the disease are expected through 2010. Its incidence is greater in the North region. One of the most crucial factors to the spawning of this kind of cancer is the presence of an infection caused by the HPV (Human Papillomavirus). By itself, this virus can t lead to carcinogenesis. Some studies suggest the presence of Chlamydia trachomatis as a co-factor in its development. This study s goal was to investigate the co-infection of HPV and C. trachomatis in cervical samples with normal and altered cell biologies. Its consisted of a transversal study, where two groups were applied: GROUP I, made of 152 women who showed pre-malignant and malignant cervical injuries, and GROUP II, of 164 women who showed inflammatory cell biology. The HPV/C. trachomatis co-infection was detected through PCR and the two HPV types were detected by sequencing. Co-infection was found in 27,1% (41/152) of women in GROUP I and 3,75% in GROUP II s. The connection between the co-infection and the environmental, socio-economic and clinical factors was observed only to the variable HPV type (p=0,0424) which associates HPV 16 to 64,1% of co-infected women.