Estudo químico e biológico dos constituintes do Cerne de Abuta Refescens AUBL. (Menispermaceae)

Abstract

The bôta, Abuta rufescens Aubl. (MENISPERMACEAE), is a medicinal plant used popularly in the treatment of malaria, uterine inflammations, hepatic illnesses and gastric ulcer, besides having action as antimycotic, diuretic and abortive. Previous chemical studies had disclosed to the presence in its stem of oxoaporphines and azafluoranthenes alkaloids. Of the chromatographic fractionate of the extract of stem in dichloromethane it was isolated, from chromatographic techniques, a crystal in form of orange needles that was identified through spectrometric methods (IR, MS, 13C NMR, 1H NMR) as the Homomoschatoline alkaloid. This work tells the gotten results of the toxicity evaluation of this alkaloid by the bioessay in Artemia franciscana, and of antitumoral activity with ancestries of cells of human breast tumors (Mcf-7), of human colon (Hct-8), of promielocitic human leukemia (Hl-60) and tumor skin (B-16).