Estudos químicos e biológicos de fitoconstituintes isolados de peltodon radicans

Abstract

Most of the snakebite incidents in the Amazon region involve the Bothrops atrox, whose venom presents the most potent edematogenic and necrotic activities in the genus. This work describes the studies of isolation of the chemical constituents and antiedematogenic activity of the species Peltodon radicans (Lamiaceae), which is used in the treatment of snakebites and scorpion stings in the region. The extracts presented aliphatic hydrocarbons, 3-OH,-amirin (1), 3-OH,-amirin (2), -sitosterol (3), stigmasterol (4), ursolic acid (5), 2,3,19-trihydroxy-urs-12-en-28-oic acid (tormentic acid, 6), methyl 3-hydroxy,28-methyl-ursolate (7), sitosterol-3-O--D-glucopyranoside (8), and stigmasterol-3-O--D-glucopyranoside (9). The flower extracts presented the largest antiedematogenic activity. This is the first report on the study of the flowers, stem, and roots of this plant.