Avaliação do potencial genotóxico de géis de clareadores caseiros

Abstract

At-home bleaching modality has been widely used in the last decades because it is considered safer for the dental element and has proven clinical efficacy. The aim of this study was to evaluate the genotoxic potential of 10% hydrogen peroxide (PH) in patients submitted at-home bleaching using a tray and two types of bleaching strips. The volunteers included in the study were randomly divided into: TOB Group - Oral B whitening strips; TUD Group - Ultradent whitening strips; And MPH Group - trays. The sample size was 20 participants per group for a study with 80% power and 5% alpha. The evaluation was done through the Micronucleus test, in three periods: before the bleaching procedure (D0), immediately after the end of treatment (D14) and 30 days after the end of treatment (D30), from the count of 1000 Cells. Data were submitted to the Shapiro-Wilk normality test and the Kruskal-Wallis-Dunn test that showed that there was no significant difference between the groups and between the periods analyzed (p = 0.0109). It was concluded that there was no genotoxicity of hydrogen peroxide (PH) to 10% in patients submitted to home bleaching in the different forms of application tested and in the periods evaluated.