A expressão da ciclina D1 nos bócios submetidos a tireoidectomias em Manaus

Abstract

The goiters stand out among the hyperplastic thyroid pathologies by high prevalence in the Amazon region. Manaus, in recent decades, receives patients with goiter from the states of Pará to Acre in search of treatment of their pathologies. This work evaluated the immunoexpression of cyclin D1 in a qualitative way in surgical specimens with histopathologic diagnosis of goiter patients undergoing thyroidectomy in Manaus / AM. Forty-one selected patients with a histopathologic diagnosis of goiter, and from the paraffin blocks of histopathology, immunohistochemistry analysis submitted to the expression of cyclin D1. Data were analyzed according to the association between the expression of cyclin D1 and the diagnosis of goiter adopting the index of statistical significance (p <0.05) and the odds ratio (OR). Of the 41 patients, 36 (87.8%) were women, with a mean age of 48 years. Twenty (48.8%) patients were positive for the expression of cyclin D1 and the observed correlation between histopathology and the results were positive for cyclin D1 (Pearson correlation = 26.1%) for goiters. The chance of a female patient have resulted positive for cyclin D1 is 4.5 times higher than in male patients (OR = 4.5). But even if the absolute majority of cases positive for cyclin D1 is female, a statistical correlation was not significant for the genre - Fisher exact test (p-value = 0.16). Commonly regarded as a marker of cell differentiation in malignant thyroid lesions, where may perform a function the cell multiplication, this study showed that cyclin D1 may be present also in benign hyperplastic lesions, such as goiters on Amazon.