Perfil farmacoterapêutico de pacientes, em uso de antimicrobianos, internados em hospital cardiológico de alta complexidade

Abstract

Objective: This study aims to establish the pharmacotherapeutic profile of hospitalized patients using antimicrobials in a high complexity cardiology hospital located in the state of Amazonas. Methods: This was a primary, observational, descriptive, retrospective, crosssectional study, carried out by analyzing the prescriptions of antimicrobials dispensed from March to May 2019 to patients hospitalized in a hospital, whose collected data were analyzed and interpreted through descriptive statistics, after approval by the Ethics Committee of the Federal University of Amazonas (CAAE 9010919.6.0000.5020). Results: The variables demonstrated a pharmacotherapeutic profile with a prevalence of male patients; age between 25-89 years; admissions to the Intensive Care Units; infections originating in the hospital environment and identification of the etiological agent. It was also identified the practice of polypharmacy and the high prevalence of drug interactions associated with the combined prescription of vancomycin + gentamicin, with greater severity and potential risk of nephrotoxicity. Conclusion: Therefore, it is necessary to consolidate the actions of the Hospital Infection Control Commission (CCIH) and in particular of the clinical pharmacist, seeking to expand the knowledge of the multidisciplinary health team in the identification of potential Drug Interactions (DIs), reduce the irrational use of antimicrobials, and consequently, increasing safety standards for patients.